@Article{, title={Oral Health Status, Salivary MMP-8& Secretory Leukocyte Peptidase Inhibitor (SLPI) Among Uncontrolled Type-I Diabetes Mellitus In Iraqi Patients}, author={Rehab Faisal Ahmed رحاب فيصل احمد and Raja H. Al-Jubouri}, journal={Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد}, volume={29}, number={2}, pages={65-70}, year={2017}, abstract={Back ground: diabetes is a metabolic disease characterized by hyperglycemia that results in deficiency or absenceof insulin production. The dental caries and gingivitis/periodontitis are widespread chronic diseases in diabetes. Theaim of the present study was determined the salivary matrix metalloproteinase (MMP-8), Secretory LeukocytePeptidase Inhibitor (SLPI) and oral health status among uncontrolled diabetic group in comparison with healthycontrol group.Materials and Methods: The total sample composed of 90 adults aged (18-35) years. Divided into 60 uncontrolleddiabetic patients (HbA1c >7%) and 30 healthy control group. Unstimulated saliva was collected from each subjectwith type-I DM, BMI, duration of diabetes, HbA1c%, DMFT, gingival index (GI) and periodontal disease index wererecorded during clinical visit. Level of salivary MMP-8 and SLPI was measured by using ELISA immunoassay analysis.Results: The DMFT was highly significant higher among type-I DM group than control group (p<0.001),GI and pocketdepthwas significant difference (p=0.002, p<0.001 respectively) between two groups except the attachment losswith no significant difference (p=0.06). The Salivary MMP-8 was elevated, whereas SLPI was lowered in individuals withtype I diabetes mellitus in comparison to the healthy controls, but statistically was non-significant. Analysis amonguncontrolled diabetic patients revealed that the HbA1c% correlate positively significant with salivary MMP-8 (r=0.321,p=0.012), SLPI (r=0.276, P=0.033) andattachment loss (r=0.353, p=0.006); however the correlation between MMP-8 &SLPIwas a significant in negative direction (r=-0.395, p=0.002).Conclusion:The DMFT, pocket depth and gingival index was higher in uncontrolled diabetes group. HbA1c% waspositively correlation withMMP-8, SLPI and attachment loss in uncontrolled diabetic group. Salivary SLPI associatedinversely with significant correlation with salivary MMP-8

} }