@Article{, title={3-AMELIORATIVE EFFECT OF SELENIUM ON REPRODUCTIVE EFFICIENCY IN ADULT MALE RATS WITH THYROID DISTURBANCE}, author={Muna H. AL-Saeed and Ikbal A.H.AL-Rufaei}, journal={Basrah Journal of Veterinary Research مجلة البصرة للابحاث البيطرية}, volume={17}, number={1}, pages={21-37}, year={2018}, abstract={This study was designed to evaluate the ameliorative effect of selenium onreproductive efficiency of adult male rats with thyroid disturbance.Hypothyroidism state was induced by administration of antithyroid drug propylthiouracil(PTU) (50mg/kg.B.W.) and hyperthyroid state was induced by administration of LThyroxine(L-T4) (50μg/kg.B.W.). Selenium (Se) treated rat group was given sodiumselenite (10 μg/kg.B.W.).Sixty adult male rats of (180-200 gm) body weight were used in this study and dividedinto six main groups. Control group, PTU treated group, L-T4 treated group, Se treatedgroup, Se+PTU treated group and Se+L-T4 treated group. All these groups weredrenched orally by gavage tube for two months.The obtained results revealed that hypothyroidism is accompanied by significant(P<0.05) decrease in serum T3, T4 concentrations compared with control and anothertreated groups and significant increase (P<0.05) in hyperthyroidism group a comparedwith control. On the other hand, TSH concentration showed a significant (P<0.05)increase in hypothyroidism group and significant decrease (P<0.05) in hyperthyroidismgroup as compared with control and another treated group.A significant decrease in serum concentrations of FSH, LH and testosterone have beenshown in serum of hyper- and hypothyroidism groups.Semen analysis showed a significant decrease (P≤0.05) of epididymal spermconcentration, sperm motility, and viability and a significant increase (P≤0.05) of sperm22abnormalities were recorded in PTU and L-T4 groups compared with control and anothertreated group. While a significant increase (P≤ 0.05) of epididymal sperm concentration,sperm motility and viability and a significant decrease (P≤ 0.05) of sperm abnormalitieswere recorded in Se alone, Se+PTU group and Se+L-T4 group. Also, histologicalexamination on the testis showed that rats treated with Se, Se+PTU and Se+L-T4 hadnormal architecture of seminiferous tubules with different stage of spermatogenesis.Whereas, rats treated with L-T4 alone or with PTU exhibited vacuolation ofspermatogonia and suppression of spermatogenesis.

} }