TY - JOUR ID - TI - Evaluation of the salivary biomarkers creatine kinase (CK) & blood urea nitrogen (BUN) activities before& after non surgical periodontal treatment in patients with chronic periodontitis AU - Maha Sh. Mahmood PY - 2011 VL - 23 IS - 4 SP - 107 EP - 111 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - ABSTRACT
Background: Host responses to periodontal disease include the production of different enzymes that are released by
stromal, epithelial or inflammatory cells into saliva & gingival crevicular fluid (GCF).
Aim of the study: to assess the difference in the activity of CK &BUN enzymes in the saliva of male patients with
chronic periodontitis before & after non surgical periodontal treatment & to evaluate the correlation between these
enzymes& probing pocket depth &relative attachment level.
Materials & methods: Measurements of plaque index (PlI),gingival index(GI) , bleeding on probing (BOP) , probing
pocket depth (PPD) &relative attachment level (RAL) were taken from male patients suffering from chronic
periodontitis before perio dontal treatment & one month after treatment .
Saliva was collected for biochemical analysis of the enzymes creatine kinase & blood urea nitrogen.
Results: The results have shown that after conventional periodontal therapy, the activity of these enzymes was
significantly decreased .There was a correlation between the activities of these enzymes & probing depth .Also there
was a strong correlation between CK enzyme & relative attachment level.
Conclusion: Based on these results, it can be assumed that the activity of these enzymes in saliva, as biochemical
markers for periodontal tissue damage, may be useful in the diagnosis, prognosis & evaluation of periodontal therapy
effects in periodontal disease.
Keyword: Salivary markers, periodontal disease. (J Bagh Coll Dentistry 2011;23(4):107-111).

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