TY - JOUR ID - TI - Prevalence of Hypothyroidism in Type 2 Diabetic Female Kurdish Subjects AU - Sarheed Jabar Muhammed, Dashti Habbas Albustani PY - 2018 VL - 15 IS - 4 SP - 286 EP - 290 JO - Medical Journal of Babylon مجلة بابل الطبية SN - 1812156X 23126760 AB - Background: The incidence of thyroid disorders is more prevalent in type 1 diabetes compared to type 2 diabetes, due to associatedautoimmune disorders. Physiological and biochemical interconnection between type 1 diabetes mellitus and autoimmune thyroiddisease is now stimulating subject of study. Objectives: The objective was to assess the prevalence of thyroid dysfunction among type 2diabetic Kurdish females and to explore the correlation between metabolic syndrome components and autoimmune thyroid abnormality.Materials and Methods: The study included 60 type 2 diabetic Kurdish females and 30 sex‑ and age‑matched controls. All patients in thestudy were exposed to anthropometric characteristics, including HbA1c, lipid profile, serum uric acid, thyroid‑stimulating hormone (TSH),free triiodothyronine, free thyroxine, anti‑thyroid peroxidase (TPO), and anti‑thyroglobulin (anti‑Tg). Results: Primary hypothyroidismwas found in 24 (40%) diabetic patients (5.67 ± 3.35 μIU/mL) versus three (10%) controls (1.76 ± 1.19 μIU/mL) (P < 0.001). Anti‑TPOwas found in 66.7% (367.21 ± 234.53) of diabetic patients versus 10% (31.78 ± 32.14) of controls (P ˃ 0.001). Anti‑Tg was found in60% (499.98 ± 358.14) of diabetic patients versus 0 (53.27 ± 36.23) controls (P ˃ 0.001). A significant positive relationship was estimatedbetween both TPO antibodies and Tg antibodies and TSH (P = 0.05 and P = 0.001, respectively) in diabetic patients. Conclusion: Autoimmunethyroid disorder is more prevalent in Kurdish women with type 2 diabetes than nondiabetic women, and thus points to a role of autoimmunityin the pathogenesis of type 2 diabetes.

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