TY - JOUR ID - TI - Role of Hepcidin in Hearing Loss AU - Sami R. Al‑Katib, Yasir L. Hasson1, Rawaa H. Shareef2 PY - 2018 VL - 15 IS - 4 SP - 376 EP - 380 JO - Medical Journal of Babylon مجلة بابل الطبية SN - 1812156X 23126760 AB - Background: Hearing loss is considered as a public health problem that affects the population at all ages. Hepcidin is an important proteinwith a crucial role in the homeostasis and metabolism of iron. Objective: The objective of this study was to evaluate the association betweenhepcidin and hearing loss and to find out the mechanisms that lead to this association. Materials and Methods: A total of 300 persons includedin this study, 150 as a patients’ group who are suffering from hearing loss and attended Al‑Sadder Teaching Hospital in Al‑Najaf Al‑AshrafCity, Iraq, while the other 150 participants who are selected randomly as controls’ group and are free from hearing loss. The ages of allparticipants ranged between 18 and 70 years, and controls were matched with patients by gender and age (within 5 years). Many parametersare measured such as hepcidin, C‑reactive protein (CRP), interleukin‑6 (IL‑6), advanced glycation end products (AGEs), and glutathioneperoxidase‑3 (GPX‑3). Results: The results of this study revealed that sensorineural hearing loss was the most common type followed bymixed one. Furthermore, it was shown that hepcidin and CRP were significantly higher in patients compared with controls, while there wereno significant differences between patients and controls in the levels of IL‑6, AGEs, and GPX‑3. The correlation analyses showed a significantpositive correlation between hepcidin and CRP and hepcidin and IL‑6. Conclusion: Hepcidin and CRP have a negative impact on hearing,increase significantly with hearing loss, and have role in the development of hearing loss.

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