TY - JOUR ID - TI - Incidence of Von Willebrand Disease Among Patients presenting with Various Bleeding Tendency to Out-Patient Clinic of the National Center of Hematology AU - Alaa Fadhil Alwan AU - Zeyad Ahmed Shabeeb AU - Hadeel duraid salman PY - 2013 VL - 2 IS - 1 SP - 37 EP - 42 JO - Iraq Joural of Hematology المجلة العراقية لامراض الدم SN - 20728069 25432702 AB - Background: Von Willebrand disease is frequent hereditary bleeding disorders with an incidence ofabout 1% in asymptomatic people. Previous Studies available around the Middle Eastdisplayed a prevalence ranged from 3 % to 34 % of Von Willebrand disease within thehereditary bleeding disorders. People with mucocutaneous bleeding represent a major subtypeof hematologic clinical presentations but simultaneously present a substantial diagnosticchallenge. On the other hand, bleeding symptoms are frequent in the general population, buttheir clinical relevance may be difficult to assess The aim of this study was to estimate theincidence of Von Willebrand disease in patients presenting with various bleeding tendencies toout-patient clinic of the national center of hematologyMethods: A total of 146 sequential patients referred to the national center of hematology betweenJanuary 2011 and April 2012 were investigated .Tests performed for the diagnosis of VonWillebrand disease included complete blood count and blood film including platelet count,bleeding time, prothrombin time, activated partial thromboplastin time, Factor VIII:C assay,and von Willebrand Factor Antigen assay.Results: Amongst 146 patients, 29 (19.8%) had Von Willebrand disease. Patients' age ranged from 1year to 65 years, with 35 males and 111 females. Menorrhagia was the most commonpresentation. Amongst vWD patients, there were 7 male and 22 female. Positive family historyin patients with VWD was found in 21 out of 29 patients (72.4 %) while positive familyhistory in bleeding tendency other than VWD was found in 47 patients (40%). Statisticalsignificant differences were found in prothrombin time, activated partial thromboplastin time,Factor VIII: C assay, and von Willebrand Factor Antigen assay between the studied groups.Conclusions: Von Willebrand disease still among the most common cause of inherited bleedingtendency in patients presented with mucocutaneous or menorrhagia, yet many cases of vWDremain undiagnosed due to wide range of clinical presentations and lack in lab diagnosis.

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