TY - JOUR ID - TI - Lipid Profile in Iraqi Children with ß-thalassemia Major AU - Jawad k.Mashaali AU - Fatma A. Obed AU - Noor Thair Tahir PY - 2014 VL - 3 IS - 2 SP - 108 EP - 115 JO - Iraq Joural of Hematology المجلة العراقية لامراض الدم SN - 20728069 25432702 AB - ABSTRACTBackground: Thalassemia are group of genetic disorders in which production of normalhemoglobin (Hb) is partly or completely suppressed because of defective synthesis of one ormore globin chains, vary from asymptomatic forms to severe or even fatal entities . Peoplewith thalassemia make less hemoglobin which results in mild or severe anemia presentas microcytic anemia. thalassemias are classified according to which chain of the hemoglobinmolecule is affected. In α thalassemias, α globin chain is affected, while in β thalassemia,production of the β globin chain is affected. Lipid abnormalities have been detected indifferent types of beta thalassemia, suggested mechanisms including plasma dilution due toanemia, accelerated erythropoiesis resulting in increased cholesterol uptake by macrophagesand histiocytes of the reticuloen-dothelial system, defective liver functioning due to ironoverload, macrophage system activation with cytokine release, and hormonal disturbances,Objectives: The purpose of the study was to examine the blood lipid profile in children withbeta-Thalassemia major in Iraq , and to determine the factors that affect it.Material and Method: Blood lipid profiles of forty-five patients between the ages of threeand ten years with beta-Thalassemia major who were receiving regular chelation therapyfollowed by from paediatric clinic of Ibn-albalady hospital were examined retrospectively.Blood lipid profiles of thirty healthy children were taken for use as the control group.Results: Hb and Hct values of the group with Beta-Thalassemia major were significantlylower than the control group . Ferritin values in the group with Beta-Thalassemia major werefound to be significantly higher than in the control group . Cholesterol, HDL-cholesterol,LDL-cholesterol levels were found to be significantly lower in patients with Beta-Thalassemia major than in the control group , while the triglyceride level was found to behigher .Conclusion: lower total cholesterol, LDL-HDLcholesterol and high TG was found in BTMgroups compared to healthy control participants. The suggested mechanisms for the decreasesin lipids are increased erythropoiesis and cholesterol consumption, iron overload, hormonalchange and oxidative stress in BTM.

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