TY - JOUR ID - TI - The prevalence of Hepatitis C Virus Infection in sample of Iraqi Patients With Non –Hodgkin's Lymphoma AU - Qudus Wamidh Jamal PY - 2015 VL - 4 IS - 1 SP - 91 EP - 100 JO - Iraq Joural of Hematology المجلة العراقية لامراض الدم SN - 20728069 25432702 AB - Background: Non –Hodgkin's Lymphoma (NHL) are monoclonal proliferation of lymphoid cells thatmay be of B-cell (70%) or T-cell (30%) origin and include many discrete entities with characteristicmorphological ,immunophenotypical , genetical and clinical features . Hepatitis C Virus (HCV) is ahepatotropic and lymphotropic virus, several studies showed that HCV may chronically infect patientswith Non–Hodgkin's Lymphoma with or without producing liver damage.Objectives: To assess the prevalence of hepatitis C virus infection in Iraqi patients with non-Hodgkin'slymphoma and to compare with two control group healthy control and patients had general medicalillnesses (unhealthy).Material and method: A prospective case control study included 40 Iraqi patients with NHL. They weretested for the presence of anti-HCV using Enzyme Linked Immunosorbent Assay (ELISA). Positiveresults were subjected to confirmatory test using Recombinant Immunoblot Assay (RIBA).The diagnosisof NHL cases was confirmed by two consultants histopathologist and they were classified according tothe Working formulation system (WF) .Two control groups was applied ; the first included 250 healthyindividuals who were age and sex matched while the second group included 50 patients suffering fromgeneral medical diseases who were age and sex matched.Result: Four out of 40 patients with Non–Hodgkin's Lymphoma (10%) were positive for anti-HCV,whereas only 1out of 250 healthy individuals (0.4%) were positive for HCV and no patient was positivein the unhealthy control group.Conclusion : The current study revealed the high prevalence of HCV infection in Iraqi patients withNon-Hodgkin's Lymphoma compared to the healthy and unhealthy control groups which support thelymphogenetic role of chronic HCV infection in the pathogenesis of NHL.

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