@Article{, title={Role of endothelial dysfunction in relation to prothrombogenesis in polycythemia vera}, author={Ibrahim A. Mahmood and Farqad B. Hamdan and Waseem F. Al‑Tameemi}, journal={Iraq Joural of Hematology المجلة العراقية لامراض الدم}, volume={7}, number={1}, pages={8-13}, year={2018}, abstract={BACKGROUND: The morbidity and mortality in polycythemia vera (PV) are closely associated withcardiovascular diseases burden and clonal evolution. These complications were primarily attributed toabnormal rheology consequent to the raised hematocrit, leukocytosis, and thrombocytosis, and in vivoactivation of leukocytes, thrombocytes, and endothelial cells. It has been established that damage ofendothelium determines the release in circulation of specific markers including thrombomodulin (TM),selectins, and von Willbrand factor (vWF) which are released and favor the formation of cellular aggregates.OBJECTIVES: The objective of this study is to evaluate the pathophysiological role of endothelialdysfunction (ED) in relation to increased risk of thrombosis in PV patients.PATIENTS AND METHODS: In a case–control study, 53 patients enrolled in this study from Al‑ImamainAl‑Khadimiyan Medical City, and the National Center for Hematology Diseases and Researches. Theycomprised of thirty patients with PV with mean age of − 54.87 ± 13.44 years‑and another twenty‑threepatients with secondary polycythemia, whose mean age was 40.13 ± 12.21 years. Another thirtyaged‑ and sex‑matched, non‑smokers healthy volunteers comprised 16 males and 14 females werealso studied, their mean age was = 52.1 ± 11.16 years. JAK2 mutation was assessed for PV groupwhile Serum erythropoietin (Epo), vWF and TM were determined for all patient and control group.RESULTS: TM was significantly different among the three studied groups (P < 0.001) as well as vWFwas significantly higher (P < 0.001) in patients with PV as compared to the patients with secondarypolycythemia and controls. Epo level was significantly lower (P = 0.004) in the newly diagnosedpatients with PV when compared to those with a history of thrombosis or longstanding disease. Thereis positive correlation between JAK2 and TM (r = 0.431, P = 0.017), while negative correlation withvWF (r = −0.565, P = 0.001) in PV patients.CONCLUSION: ED is one of mechanisms that contribute in prothrombogenesis in PV patient.

} }