@Article{, title={Investigation of Azoospermia Factor Microdeletions in Infertile Men in Diyala Governorate}, author={Muthanna A. Al-Mahdawi and Ahmed Ali Al-Azzawi and Hussain Kh. Kadhem}, journal={Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم}, volume={8}, number={2}, pages={43-49}, year={2018}, abstract={Background:Y chromosomes microdeletions (YCM) are the most frequentlyobserved structure abnormalities in the male specific region (MSY), 15% of totalprimary spermatogenic failure cases are related to at least 6 known major YCMpatterns. These microdeletions present in 5-10% of infertile men and they arevery rare in fertile and normospermia men.Objectives:This study was conducted to investigate the prevalence of AzoospermiaFactor (AZF)region microdeletions in a sample of Diyala governorate infertilemen.Subjects and Methods: An included 80 infertile men who had been referredto private clinics of New Baquba as a test group and 20 proven fertile men as acontrol group. Tests included seminal fluid analysis, sex hormones profile andpolymerase chain reaction using specific tagged sites.Results: Showed that eleven infertile men (13.75%) had AZF microdeletions,while no microdeletion were found in control group. Seven (63.6%) microdeletionswere in AZFc sub-region while 2(18.1%) microdeletions were in AZFbcand AZFb each. This study showed that men with sperm count below <5 millions/ml should be evaluated for Yq11 microdeletions before attempting any surgicalor hormonal treatment or attending assisted reproductive techniques.Conclusion:AZFc is the dominance pattern of microdeletions in Diyala governorateinfertile males and AZFa pattern of microdeletions is the rarest pattern, also geneticscreening for long arm of Y chromosome microdeletions should be listed in the routinetests for men who suffer from azoospermia prior to providing ART service orsurgical treatments.

} }