@Article{, title={THE EFFECTS OF 4̄,4 ̄̄ -(4,5,6,7-TETRAHYDRO- [1,2,3-] SELENADIAZOLO [4,5E] PYRIDINE-4,6-DIYL) BIS(BENZENE-1,3- DIOL) ON FERTILITY, REPRODUCTIVE HORMONES AND OVARIAN HISTOLOGICAL CHANGES IN FEMALE RATS TREATED WITH DIPYRONE. تأثیر مركب SELENADIAZOLO [4,5E] PYRIDINE-4,6-DIYL) BIS(BENZENE-1,3- DIOL) ) على الخصوبة والھرمونات الإنجابیة والتغییرات النسیجیة المبیضیة مقارنة مع اناث الجرذان المعالجة بالدایبایرون}, author={Nadheerah F. Neamah * Abdul-Razzak .Naaeem Khudair ** Shaker.A.N.Al-Jadaan نظیرة فالح نعمة* عبد الرزاق نعیم خضیر** شاكر عبد السالم نعمة الجدعان}, journal={Basrah Journal of Veterinary Research مجلة البصرة للابحاث البيطرية}, volume={18}, number={1}, pages={156-173}, year={2019}, abstract={The current study aimed to evaluate the effects of [ 4’,4” -(4,5,6,7-tetrahydro-[1,2,3-] selenadiazolo[4,5e] pyridine-4,6-diyl) bis(benzene-1,3-diol)] (T) on femalefertility and reproductive hormones, in addition histopathological examination of ovariesin comparison with the effects of Metamizole or Dipyrone (Di). Four groups of maturefemale rats each group consist of ten healthy female rats. Three groups received T and /orDi dissolved in drinking water 2mL (DW), the forth group received 2 mL of (DW) for 20days before mating and ten days after mating. The results indicated that there was asignificant increase in the number of births of (T) group (13.70±3.34) compared to DWgroup (9.7±1.06). Also, significant decline in T&Di group to (6.91±0.32), with nopregnancies reported in Di treated group. The pregnancy percentage was in T&Di groupbasically decline to 40% compare with T and DW groups 100%. Follicle stimulatingHormone (FSH) level showed a significant elevation (p<0.05) in T group (5.19mIU/mL157Bas.J.Vet.Res.Vol.18, No.1, 2019.±0.72), and T&Di (5.12 mIU/mL ±0.78) compared with DW (1.61mIU/mL±0.52), and Di(1.46 mIU/mL ±0.60) groups. LH concentration of T (1.88 mIU/mL ±0.48), and T&Di(1.67 mIU/mL ±0.41) groups LH values than in DW (1.75 mIU/mL ±0.67). Only in Digroup (0.88 mIU/mL ±0.48) LH value reduced significantly (p<0.05) than in other testgroups. T group (17.22 mIU/mL ±4.50) progesterone level; also T&Di groupprogesterone level (10.11 mIU/mL ±2.05) statistically important increase, while Di groupthere is essentially decreased (p<0.05) to (2.69 mIU/mL±0.89) compare to DW (6.31mIU/mL ±1.41). Histopathological results showed that ovarian section of Di groupdisclosed large cystic corpus luteum CC.L, absence of Graafian Follicles and follicles atdifferent stages of development. T group section showed normal Graafian follicles anddifferent follicles in developmental stages, as well as there were several persistencecorpus luteum. Ovary of T&Di female rats relieves improvement of some Graafianfollicles, Cystic corpus luteum (CC.L). Furthermore, there was some of clear C.L. It canbe concluded that T compound had a Good effect on the level of reproductive hormonesand increase fertility in female rats. While Di long term treatment had bad effects onfemale fertility, by affecting reproductive hormones levels and pathological change ofovaries

تھدف الدراسة الحالیة لتقییم تأثیرات مركب)(T[4̄,4 ̄̄ -(4,5,6,7-TETRAHYDRO- [1,2,3-] SELENADIAZOLO [4,5E] PYRIDINE-4,6-DIYL)BIS(BENZENE-1,3-DIOL)]على خصوبة الاناث وھرمونات التكاثر، بالإضافة الى التغییرات النسیجیة المرضیة في المبایض بالمقارنةمع تاثیرات المیتامیزول او الدایبایرون) .(Diاربع مجامیع من اناث الجرذان الناضجة وكل مجموعة تضم عشرمناناث الجرذان الصحیة. ثلاثة مجامیع أعطیت مركب ) (Tمع/ او ) (Diمذاب في ٢مل من ماء الشرب،المجموعةالرابعة أعطیت ٢مل من ماء الشرب لمدة ٢٠یوم قبل التزاوج وعشرة أیام بعد الجماع. النتائج تدل على ان ھناكزیادة معنویة في عدد الموالید في مجموعة ) (13.70±3.34) (Tمقارنة مع مجموعة ماء الشرب ).(9.7±1.06كذلك انخفاض معنوي في مجموعة T&Diالى ) ، (6.91±0.32مع عدم تسجیل حالات حمل في مجموعة المعالجةب .Diالنسبة المئویة للحمل في مجموعة %٤٠ T&Diمقارنة مع مجموعتي Tو .%١٠٠ DWمستوى ھرمونمحفز الجریب ) (FSHاظھر ارتفاع معنوي في مجموعتي ) (5.19 mIU/mL ±0.72) (Tو 5.12 ) T&Di.(1.46 mIU/mL ±0.60) Di ( و1.61mIU/mL±0.52)DW ( مقارنة مع مجموعتيmIU/mL ±0.78تركیزھرمون اللیوتین LHفي مجموعتي ،(1.88 mIU/mL ±0.48)Tو (1.67 mIU/mL ±0.41) T&Diعن تركیز LHفي مجموعة .} }