TY - JOUR ID - TI - A Higher Pregnancy Rate with GnRH Antagonist Stimulation Protocol During Intra Cytoplasmic Sperm Injection (ISCI). AU - Muhjah Falah Hassan PY - 2019 VL - 12 IS - 2 SP - 2234 EP - 2239 JO - Karbala Journal of Medicine مجلة كربلاء الطبية SN - 19905483 29580889 AB - Background: Controlled Ovarian Stimulation (COS) is a widely used method during assisted reproduction. There are two commonly used COS protocols: GnRH agonist and GnRH antagonist. Selecting the protocol for COS is the most critical decision could be made and there is no standard protocol which could be applied for all patients. Aim: The aim of this study was to compare ICSI outcome between GnRH antagonist and agonist protocols represented by oocytes maturity, fertilization rate (FR), cleavage rate (CR), embryos quality and pregnancy rate (PR).Materials and Methods: Fifty infertile females were included and they divided in to two groups according to the protocol: Group I: In which GnRH agonist was used (n=33) and Group II: In which GnRH antagonist was used (n=17). All were included in ICSI program. Following oocytes retrieval, microscopic assessment of oocytes' maturity and embryos' quality was done followed by calculation of FR, CR and PR. Results were compared between both groups. Results: The study showed that GnRH agonist-stimulated females produced slightly more immature oocytes (1.40±2.01 VS 0.94±2.13) with a lower fertilization rate with no significant statistical difference regarding CR and embryo quality. Pregnancy rate tended to be lower 42.42% when compared with antagonist protocol 58.83%.Conclusion: Both GnRH agonist and antagonist protocols have the same effect on ICSI outcome in form of oocyte maturity, FR, CR and embryo quality except PR which tends to be higher with the antagonist protocol.

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