TY - JOUR ID - TI - Beneficial Effects of Telmisartan in Treatment of Hypertension With Type Two Diabetic Patients in Salahaddin Society AU - Rafal K. Farhan AU - Sabah A. Khuder PY - 2019 VL - 25 IS - 1 SP - 165 EP - 174 JO - The Medical Journal of Tikrit University المجلة الطبية لجامعة تكريت SN - 18131638 AB - ABSTRACT:Background Diabetes is a chronic illness lead to acute complications thatrequired patient self-management education and life style care to preventcomplicationThis study aims is to determine the degree of 12 weeks telmisartan therapy on thelevel of systolic blood pressure (SBP) & diastolic blood pressure (DPB), meanarterial pressure (MAP), serum glucose level, glycated hemoglobin(HbA1c) leveland microalbuminuria (MA) as a marker of renal deterioration recently diagnosedhypertensive type two diabetes mellitus (T2DM) patients.Patients & Methods: Forty six newly diagnosed hypertensive patients with types2 diabetes mellitus participated in the study(2017); 22 males and 24 females, theirmean age was 52.93± 7.69 years. Eighty one apparently healthy persons (36 maleand 45 female), who had no chronic disease and didn't receive any chronic therapyparticipated in the study as a control group. Both groups were matched regardingage and sex. BP was measured using a mercury sphygmomanometer with thesubject waiting for a 5-minutes rest. Fasting serum glucose (FSG) concentrationwas estimated using a kit supplied by Biocon (Germany). HbA1c is measured inwhole blood sample by ion-exchange resin quantitative colorimetric determinationusing a kit supplied from Stanbio (USA). Microalbuminuria measured by detectingprotein-creatinine ratio (PCR) which include determination of urine protein bysulphosalicylic acid 3%, measuring urine creatinine by using a kit supplied fromSyrBio company and finally calculation of PCR by dividing protein concentrationin urine upon creatinine concentration in urine .Result: Showed that T2DM patients having a significant rise in SBP, DBP andMAP, also persistent hypertension lead to overt diabetic nephropathy, and there isdiabetes and hypertension have a close relationship between due to resistance toinsulin action on glucose uptake in peripheral tissues as compared with the controlgroup. After a 12 weeks telmisartan monotherapy there was a significant reductionin SBP, DBP, MAP, FSG and microalbuminuria level.Conclusion: Telmisartan has a valuable renal protective effect by decreasingproteinuria, also it have a specific antihyperglycemic effect beyond angiotensin IIreceptor antagonism in addition to its hypotensive effects.Key words: Type two diabetes mellitus, microalbuminuria, Telmisartan

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