@Article{, title={Seroprevalence of Antinuclear Antibodies, Antibrucella Antibodies, and Hepatitis B Surface Antigen in Women with Recurrent Abortion}, author={Nabaz Fisal Shakir Agha}, journal={Medical Journal of Babylon مجلة بابل الطبية}, volume={17}, number={2}, pages={159-164}, year={2020}, abstract={Background: Recurrent abortion is a globally common problem. Many factors play a crucial role in the pathogenesis of abortion such as antinuclearantibodies (ANA), antibrucella antibodies and hepatitis B surface antigen (HBsAg). Objectives: The study objective was to estimate the serumlevels of antinuclear antibodies (ANAs), antibrucella antibodies, and hepatitis B surface antigen among recurrent aborting women. Materials andMethods: One hundred and twenty women were enrolled in this prospective case–controlled study from Maternity Hospital, Erbil City, Iraq. Thestudy included sixty patients with a history of three and more attacks of previous abortions and sixty healthy pregnant women. All were screenedfor ANA‑IgG, antibrucella antibodies, and hepatitis B surface antigen (HBsAg) in serum. Results: It was noted that 15/60 (25%) patients and6/60 (10%) healthy controls were positive for ANA‑IgG with a mean concentration of 6.2 ± 0.4 IU/ml in the patient group and 0.75 ± 0.325 IU/ml in the healthy controls with statistical significance at P ≤ 0.05. The distribution for ANA with antibrucella and HbsAg in patient group was asfollows: 12/15 (80%) and 6/15 (46.15%), respectively, among the seropositive ANA patients with a high significance at P < 0.01 for antibrucellaand a significance at P < 0.05 for HbsAg. Conclusions: ANAs constitute an important cause of recurrent mid‑trimester abortion in women.Furthermore, there is growing clues of the pathogenicity of Brucella organisms and hepatitis B virus, especially as agents of adverse pregnancy.

} }