TY - JOUR ID - TI - Synthesis and Characterization of New Compounds Derived from Pyrrolidine-2-One and Evaluation of their Biological Activities AU - Nadia A. Betti AU - Redha Ib. Hussain AU - Sahar Ab. Kadhem AU - Abdul Jabar Kh. Atia PY - 2020 VL - 23 IS - 4 SP - 5 EP - 12 JO - Al-Nahrain Journal of Science مجلة النهرين للعلوم SN - 26635453 26635461 AB - New derivatives of pyrrolidine-2-one have been prepared by lactamization of -butyrolactone GBL with hydrazine hydrate (NH2NH2 (80%)) to afford (1-aminopyrrolidin-2-one) which undergo many reactions to prepare the other derivatives. The prepared derivatives were determined by utilizing their FT-IR, 1H-NMR and some by Mass spectrum. These derivatives were evaluated biologically against (Staphylococcus aureus and E. coli). Some of these derivatives exhibited good biological activity against one or both kind of bacteria while some exhibited no biological activity at all.

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