TY - JOUR ID - TI - High Prevalence of Vitamin D Deficiency in Patients with Acute Myocardial Infarction: An Iraqi Single‑Center Study AU - Shwan Othman Amen1, Soza Tharwat Baban2, Salah Hassan Yousif3, Zana Tharwat Baban4, Ahmed Himdad Hawez1, Dlovan Mustafa Fateh Jalal5 PY - 2020 VL - 17 IS - 4 SP - 358 EP - 362 JO - Medical Journal of Babylon مجلة بابل الطبية SN - 1812156X 23126760 AB - Background: Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide despite current advances in primarypreventive and state‑of‑the art interventional strategies for effective CAD treatment. The major manifestation of CAD is the acute myocardialinfarction (AMI). Vitamin D deficiency is associated with an increased risk of coronary atherosclerosis and AMI. Objectives: The major aim of thisstudy was to determine the association of Vitamin D deficiency with AMI in Iraqi patients living in this region. Materials and Methods: VitaminD level status was determined in 148 patients presented with AMI and 148 of healthy controls. Measurement of serum 25‑hydroxyvitaminD (25(OH) D) levels was performed using enzymatic immunoassay method. Normal serum 25(OH) D level is ≥ 30 ng/ml, while patients withlevel of 20–30 ng/ml was classified as insufficient, and those with level 10–20 ng/ml as deficient. The severe Vitamin D deficiency in patientswas defined when serum 25(OH) D level was ≤ 10 ng/ml. Results: The mean of 25(OH) D level was significantly lower in patients withAMI (8.73 ng/ml) as compared to healthy controls (13.60 ng/ml). Notably, the prevalence of severe deficiency of 25(OH) D level (<10 ng/ml)was higher in patients with AMI (67.6%) as compared to that in healthy controls (51.4%). This difference was statistically significant. Similartrend was observed for the prevalence of deficient Vitamin D level (≥10–<20 ng/ml) in cases (28.4%) as compared to control group (24.3%).Moreover, 4.1% of AMI patients showed insufficient 25(OH) D level in comparison to 13.5% in healthy individuals of control group. Interestinglythere were no AMI patients with sufficient 25(OH) D level (30–100 ng/ml) while 10.8% of healthy individuals in the control group showedsufficient 25(OH) D level. Conclusions: This study concludes that Vitamin D deficiency is a highly prevalent condition in patients with AMIamong Iraqi population and it is an emerging new risk factor associated with AMI.

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