@Article{, title={Evaluation the Effect of Folic Acid on Some Inflammatory Mediators; IL-6 and TNF-α in Chronic Gingivitis Patients}, author={Faehaa Azher Al-Mashhadane and Rawia Fehr Al-Basrawi}, journal={Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان}, volume={21}, number={1}, pages={25-34}, year={2021}, abstract={Aims: To evaluate the anti-inflammatory effect of systemic treatment with folic acid and relation to oral health indices of patients with chronic gingivitis. Materials and Methods: Forty patients were classified into two groups; Group 1: (n:20) chronic gingivitis patients, did not receive any medications (control group), Group 2: (n:20) chronic gingivitis patients (treatment group), received 1 mg/day oral tablet of folic acid for 42 days. Scaling and polishing have been carried out for each volunteer to reach the base-line for the gingival index and oral hygiene index. In the next day, these indices were measured for all participants, then measured after 21 days then after 42 days of treatment. In each visit, five milliliters of unstimulated saliva were collected for measurement of salivary IL-6 and salivary TNF-α by human salivary ELISA kits. Results: There is a significant decrease in salivary TNF-α level between treatment group and control group, while there is a nonsignificant decrease in levels of salivary IL-6 at 21st and 42nd day. There is no significant difference in gingival index and oral hygiene index between treatment and control group. Conclusions: sub-acute using of oral supplementation of 1mg / day folic acid in chronic gingivitis patients improves their gingival health by reducing TNF-α level in their saliva.

} }