TY - JOUR ID - TI - Ceruloplasmin Activity and Ferritin in Patients with Chronic Liver Disease AU - Mohammed Hussein Habeeb AU - Mufeed Jalil Ewadh AU - Mazen Jaafer Mousa PY - 2021 VL - 18 IS - 3 SP - 257 EP - 260 JO - Medical Journal of Babylon مجلة بابل الطبية SN - 1812156X 23126760 AB - Background: Ceruloplasmin (CP) is a copper-containing glycoprotein found in the globulin portion of human blood serum 2. CP,a glycoprotein secreted by hepatocytes, carries more than 90% of copper in the bloodstream of healthy people. CP is an effectiveantioxidant that prevents lipid peroxidation by removing oxygen. CP inhibits lipid peroxidation initiation. CP has function also knownas an extracellular superoxide dismutase species (SOD) that neutralizes radicals of superoxide anions. Aims: The aim of this study isto understand the status of CP in chronic liver disease (CLD) patients, which could yield important information regarding the overalloxidative stress and iron storage. Out of the total 86 samples, 50 samples were patients who have been diagnosed with CLD, especiallychronic hepatitis B virus (HBV) and hepatitis C virus (HCV), collected from the Center of Internal Medicine and Cardiology inMarjan Teaching Hospital in Hillah city, Babylon Province, Iraq and other samples were healthy controls. Materials and Methods: TheCP oxidase activity test was processed by PPD buffer oxidation. Ferritin concentration was tested by enzyme-linked immunosorbentassay. Results: There were no significant differences in levels of ferritin between HBV and HCV patient groups, but there are slightincreases in the mean of CP activity in the HCV patients. A positive significant correlation was observed between CP activity andferritin. Conclusion: 1. CP activity increases in CLD patient and in HCV more than HBV. 2. CP activity is affected by viral load soit increases in positive viral load patients compared with negative viral load patients. 3. There was a positive correlation between CPactivity and ferritin. 4. Serum ferritin is not affected by CLD.

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