@Article{, title={EVALUATION FOR ANTIBACTERIAL AND ANTIPROLIFERATIVE ACTIVITY AGAINST CANCER CELL LINES OF BIOSYNTHESIZED SILVER NANOPARTICLES FROM VITEX AGNUS-CASTUS AND UNCARIA TOMENTOSA EXTRACTS}, author={maytham.abdulkadir@uobasrah.edu.iq and SUHA M.A. Al-MUDHAFAR}, journal={Journal of Basrah Researches (Sciences) مجلة ابحاث البصرة ( العلميات)}, volume={47}, number={1}, pages={70-93}, year={2021}, abstract={The present study aims to investigate the biosynthesis of silver nanoparticles using the aqueous extract of the Vitex agnus-castus (leaves and flowers) and Uncaria tomentosa (branches with claws) and investigate their antimicrobial and anticancer activities. In order to synthesise the silver nanoparticles, aqueous extract of the plant was prepared and introduced into a 1mM silver nitrate solution. The synthesised Ag NPs were characterised using various instrumental techniques, involved Scanning electron microscope (SEM), Ultraviolet-visible spectroscopy, Fourier transformed infrared spectroscopy (FTIR). Surface Plasmon Resonance (SPR) for AgNPs was noted at 390 nm using V. agnus-castus and U. tomentosa extracts. The synthesized AgNPs of V. agnus-castus and U. tomentosa were found with average diameter of 40.85- 49.41nm, 30.69- 54.53nm respectively. The antibacterial result (inhibition zone) against the experimental pathogens was found to be ranged between 12 to 24 mm and from 10 to 20 mm respectively. Toxicity effect of AgNPs against cancer cells was 75.46 of 50 µg/ml and 76.67 of 50 µg/ml respectively. In this research, silver nanoparticles of the plant extracts studied have antimicrobial against some bacterial strains and anticancer against breast cancer cells.

} }