TY - JOUR ID - TI - Phytochemical analysis and antibacterial activity of some medicinal plantsagainst methicillin-resistant Staphylococcus aureues التحليل الكيمياوي والنشاط المضاد للبكتريا لبعض النباتات الطبية ضد المكورات العنقودية المقاومة للمثيسيلين AU - Suhaila N. Darogha سهيلة نافع داروغة PY - 2009 VL - 5 IS - 2 SP - 116 EP - 126 JO - Tikrit Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية SN - 18152716 2664231X AB - Tlre objective of this study is, first to report the prevalence of methicillin resistant Staphylococcus
aureues (MRSA) infections and their antibiotic susceptibility patterns in Teaching and Emergency
Hospital in Erbil city, and second to screen four medicinal plants: Eucalyptus globulus, Anethunt
graveolens, Prosopis farcta and Ficus carica (both aqueous extract and ethanolic extract) for potential
antibacterial activity against MRSA isolates, then screening the phytochemical properlies of these plants.
Out of total 1 10 strains of Staphylococcus aureues isolated from different clinical specimens, 5 (13.6%)
were found to be methicillin resistant. All MRSA strains were found to be resistant to penicillin and
gentamycin while 86.66% were resistant to cephalothin ,doxycyciin and tobramycin. However, no strains
were resistant to vancomycin. Determination of rninimal inhibitory concentration (MIC) and minimal
bactericidal concentration (MBC) values were performed using micro broth dilution method. The
MIC/,IBC of aqueous and ethanolic extracts of E. gtobulzus against MRSA isolates were 25112.5 mg/ml
and 6.2513.125 mg/ml respectively, while of P. farcta werc 100125 mg/ml and 25112.5 mg/ml
respectively. The results also revealed that extracts of F. carcia were inactive against MRSA. Preliminary
phytochemical analysis revealed the presence of tannins and phenols in almost all the crude extracts
followed by alkaloids and resins, while the glycosides was not detected in any extracts of the four plants
tested.

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