@Article{, title={Correlation Betveen Erythromycin- Resistance Phenotypes ofStreptoco cc us Pne unrc nifi e ancl the Invitro Activitl' of Telith romycineand Azithrornycine العلاقة بين الانماط المظهرية المقاومة للارثرومايسين لبكتريا المكورات السبحية الرئوية والفعالية خارج خلوية للتليرومايسين والازثرومايسين}, author={Nuha Saleem Mohammed AIi نهى سليم محمد علي}, journal={Tikrit Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية}, volume={3}, number={2}, pages={127-134}, year={2007}, abstract={Tow principal mechanisms have so far been found to be responsible for acquired
nracrolide ,lincosamide and streptogramin B (MLSB) antibiotics resistance in Streptoioccus
pneumoniae : :target site modification and active drr.rg efflux .the target site moclification is due to
methylase ,prevents the binding of the antibiotic to its ribosomal target and can be expressed either
in a constittttive (cMLS phenotype) or inducible (iMLS phenotype ) manner .the malrolide efflux
system,M phenotype ,is mediated by a membrane protein responsible for the efllLrx resistance.
Although the incidence of resistance to macrolides rvas low in the past,today t5c- ilciclence reported
by several countries shorvs a sensibie increase. Thus it is necessary to search and test novel
antimicrobial agents characterizecl by a spectrum of activity against the most collnton respiratory
patlrogerrs. This study conrpared the invitro activity (MIC and MBC) of telithroprl,cin f ith activity
of azithromycin against Streptococcus pneumonictc recently isolatecl liom sap (lioyanni Battista
I-tospital (Ttrrin,ltaly). Erythromycin - resistance phenotypes w'ere cleternrinccl thro996 a triple - disk test to correlate a potential diflerent bacterial pattenr to antinricrobial rr'r..ptibility. The
incidencc of er1'thronrycin-resistflltce was 26.66%.ln the groLrp of Ery-li Streptogot'c.tr.s pneumonicte
58'33% strains belonged to cMLS phenotype, 33.33% to M phenotype ancl 8.3j% to iMLS
phenotype. Telithromycin preseuted MIC values lo*'er tfian those cletecteA fith azithromycin
against all isolated straius Telithromycin appearecl to be highly active against Streptococctts
ltttcumonictc, in particttlar r.vhen resistance is nrediated by the efflgx slstem cop[irptipg its clilical
e ff rcacy antong respi ratory streptococcal in fections.

} }