TY - JOUR ID - TI - The role of selective serotonin re-uptake inhibitors in themanagement of premature ejaculation دور مثبط الاسترجاع الانتقائي للسيروتونين في علاج تأخير القذف المنوي AU - Yasir I. Abass Al-Janabi ياسر عباس الجنابي PY - 2008 VL - 4 IS - 2 SP - 88 EP - 94 JO - Tikrit Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية SN - 18152716 2664231X AB - A prospective, randomized, placebo-conlrolled study was designed to investigate the efticacy and
side effects of the selective serotonin re-uptake inhibitor, fluoxetine hydrochloride, on postponing
ejaculation in patients with premature ejaculation (PE). A total of 55 men with PE were scheduled
to begin this study, but 5 of them have been dropped out for unknown reason, so tbc study was
completed with a total number of 50 patients. The ages of these patients (who experienced primary
premature ejaculation (lifelong rapid ejaculation)) ranging between 19 to 65 years. The patients
were asked to detennine the time in seconds between vaginal penet.ration and ejaculation (latency
time), by using a clock for four weeks before starting the trcatment,and a baseline mean
ejaculatory latency time was measured. Then the patients were given either flouxetine
hydrochloride or placebo for aditiomal 8 weeks. All patients were interviewed before and 8 weeks
after beginning the treatment.Baseline mean ejaculatory latency time was 60.6 s; 20 mg/day of
lluoxetine increased it to 199.3 s, while in patient using placebo it was 68. 15 s (p < 0.001). This
resulted in significantly greater sexual satisfaction for men: 73% (p < 0.001). Generally. fluoxetine
was well tolerated and there were no major side effects. None of the patients discontinued thempy
due to adverse effects. Fluoxetinae hydrochloride may be regarded as a safe and effective option in
the treatment of premature ejaculation.

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