TY - JOUR ID - TI - In vitro Inhibition of Human Plasma and Erythrocyte Cholinesterases by a Selected Drugs (Enzymes Inhibitors) تنشيط إنزيم الكولين استيريز في كريات الدم الحمر وبلازما الدم في الانسان بواسطة عدد من الادوية AU - Omer A.H. Ahmed AU - Ahmed A.J. Mahmood PY - 2011 VL - 7 IS - 2 SP - 143 EP - 151 JO - Tikrit Journal of Pharmaceutical Sciences مجلة تكريت للعلوم الصيدلانية SN - 18152716 2664231X AB - The inhibitory effect for human plasma and erythrocyte cholinesterase activity by six drugs already known as an enzyme inhibitors (Cimetidine, Ciprofloxacin, Donepezil, Sildenafil, Erythromycin, and Chlorpheniramine) was tested in vitro. The affinity toward the cholinesterase system was evaluated by using different concentrations of the investigated drugs. The cholinesterase activities were determined by using the modified electrometric method. Each drug showed different ability to inhibit cholinesterase activity depending on its concentration and its selectivity to the either plasma or erythrocyte cholinesterase; only Donepezil and Chlorpheniramine showed higher inhibitory effect. Ciprofloxacin showed moderate inhibition of cholinesterase but still statistically insignificant. Cimetidine, Sildenafil and Erythromycin showed little inhibitory activity although they have a good inhibitory effect on the liver enzyme system Cytochrome P450 (CYP450 ).

ER -