TY - JOUR ID - TI - Types of chromosomal abnormalities caused by chemotherapy cyclophosphamide in mice (Mus musculus L.) أنواع تشوهات الكروموسومات التي يسببها العلاج الكيميائي سيكلوفوسفاميد في الفئران AU - Wasan Moayad Shaker and Zainab Abdul Rahman Mohammed Al tuma PY - 2022 VL - 21 IS - 1 SP - 107 EP - 123 JO - Basrah Journal of Veterinary Research مجلة البصرة للابحاث البيطرية SN - 18138497 24108456 AB - The current study was designed to study the genetic effects of Mus musculus L. on male andfemale laboratory mice. The study included the following: Cyclophosphamide's effects onchromosomal changes in bone marrow cells and testes, as well as a study of Cyclophosphamide'seffects on the mitotic index of bone marrow cells and germ cells (testes). Cyclophosphamidedosing resulted in a (0.006mg/kg body weight) for 30 days . Chromosomal changes appear inbone marrow cells (chromatid gap, chromatid break, centromere gap, ring chromosomes,centromere break, deletion) within a statistically significant difference (0.004).Cyclophosphamide also led to the occurrence of chromosomal changes in testicular cells(chromatid gap, centromere break, centromere gap, ring chromosomes, polyploidy) at astatistically significant difference (0.046). The results of the study also showed that the activityof cyclophosphamide caused a significant decrease in the mitotic index of bone marrow cells atthe duration of the dose . at a statistically significant difference (0.016). For calculating themitotic factor of the germ cell (testes), the results showed a decrease in the dose while there wereno significant differences (p≥0.05).

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