TY - JOUR ID - TI - Eremostachys Binalodensis, A Potential Therapeutic Choice for Gingival Inflammatory Wounds AU - Armin S.Hariri, Sevda Shayesteh, Parina Asgharian, Mohsen Chamanara, Maryam-Sadat Sadrzadeh-Afshar PY - 2021 VL - 07 IS - 03 SP - 140 EP - 144 JO - Journal of Contemporary Medical Sciences مجلة العلوم الطبية المعاصرة SN - 24151629 24130516 AB - ObjectivesIn this study we aimed to evaluate the effect of E. binalodensis on gingival inflammatory wounds. Materials and MethodsIn-vitro wound was induced by scratching the surface layer of human gingival fibroblasts (hGFs). Cells were retreated with 1,10,100,1000 μg/ml of E. binalodensis methanol extract prior to 1 μg/ml LPS stimulation. hGFs proliferation was assessed by MTT test. Also levels of critical inflammatory cytokines such as IL-1b, IL-6 and TNF-a were determined by enzyme-linked immunosorbent assay (ELISA). Results Wound induction was associated with secretion of IL-1β, IL-6 and TNF-a from hGFs. E. binalodensis enhanced the hGFs proliferation besides reducing the level of IL-1β, IL-6 and TNF-a in LPS-scratch-stimulated hGFs. Conclusions Regarding anti-inflammatory and proliferative effects of E. binalodensis on hGFs, availability and safety of it, it is suggested for enhancing the wound healing process in gingival inflammatory wounds.

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