@Article{, title={Epstein- Barr Virus In Iraqi Patients With Nasopharangeal Carcinoma}, author={Batool Mutar Mahdi}, journal={Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية}, volume={5}, number={2}, pages={204-208}, year={2006}, abstract={ABSTRACT:BACKGROUND:Epstein-Barr virus (EBV) was ubiquitous Herpes virus that had a role in the development ofundifferentiated carcinoma of the nasopharynx, Burkett’s lymphoma, acute infectious mononucleosisand other lymphoprolifrative disorders.METHODS:Thirty Iraqi patients with nasopharangeal carcinoma were referred to Oncology Unit in Al-KadhemiaTeaching Hospital from 1992-1994. Sera of those patients were tested for the presence of antibodiesagainst Epstein-Barr virus nuclear and early antigens using indirect immunoflourescence test.Cellular immunity for those patients was tested for the CD4+, CD8+, CD4/CD8 ratio, T-cells % andB -cells %. Their results were compared with twenty-two normal apparently normal individuals.RESULTS:Antibodies to Epstein-Barr virus nuclear and early antigens were detected in nasopharangealcarcinoma Iraqi patients and not in the control group. There was significant difference between twogroups in CD8+ cells, T- cells % and B- cells % and there was no significant differences between twogroups in CD4+ cells, CD4/CD8 ratio.DISCUSSION:EBV infection was stopped by T- cells immune response that was capable of eliminating virusinfected cells and virus neutralizing antibodies against nuclear and early antigens which prevent thespread of infection. Lymphocytes were predominantly CD8+ cytotoxic T lymphocytes, whichrecognize and destroy EBV infected cells.RECOMMENDATIONS:Other antibodies to viral capsid antigens (IgG, IgA and IgM). Other methods must be used other thanindirect immunoflourescense test like western blot method and enzyme linked immune sorbent assay(ELISA).

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