@Article{, title={Evaluation of EBV serum and salivary IgA antibodies level in head and neck cancer patients}, author={Ahmed Sahib Abdulamir}, journal={Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية}, volume={5}, number={2}, pages={209-212}, year={2006}, abstract={ABSTRACT:BACKGROUND:Many previous studies revealed that salivary and serum IgA response to infectious agents such asEBV-coded antigens in patients with nasopharyngeal carcinoma (NPC) had a vital role in thecombat against tumorigenesis. Moreover, it could be considered as a reliable index for the humorallimb of anti-cancer immunological action.METHOD:One hundred twenty two head and neck cancer (HNCA) patients were selected randomly from twomain hospitals, Alkadhimya hospital and radiotherapy center in Baghdad. Also 100 apparentlyhealthy control subjects (HC) underwent the same examinations and tests. Enzyme-linkedimmunosorbent assay (ELISA) test was applied on all HNCA patients sera and saliva, in order tomeasure anti-EBV IgA antibodies .RESULTS:Revealed that NPC patients were the only group that showed a sero-positive ELISA readings of anti-EBV serum IgA. No saliva EBV antibodies were detected in the studied groups .CONCLUSIONS:S.IgA level seems to be an applicable index for evaluating EBV burden originated fromnasopharyngeal cancerous cells. Such index might help in diagnosing early and specifically thecarcinogenesis of NPC, moreover, might help in evaluating the progress of the disease.

} }