@Article{, title={The Clot-lysis Effect of Selective α1-Adrenoceptor Antagonist in Vitro Model Associated with High Peroxynitrite Level}, author={Marwan S.M. Al-Nimer and Ali Ismail A. AL-Gareeb and Hayder M. Al-Kuraishy}, journal={Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية}, volume={10}, number={2}, pages={269-272}, year={2011}, abstract={ABSTRACT:BACKGROUND:Alpha1-adrenoceptor blocking agents showed several effects beyond their action on the vascular smooth muscles. They improve the lipid profile and inhibit the aggregation of blood platelets.OBJECTIVE:To investigate the clot-lysis effect of selective α1-adrenoceptor antagonists and its relation to peroxynitrite level in vitro experimental model.MATERIALS AND METHODS:Venous blood samples obtained from ten healthy subjects. To each pre-weighed clot, 100 μL of either distilled water as a negative control, prazosin (10 μg), terazosin (20 μg) and alfuzosin (25 μg) were added. Peroxynitrite level was measured in sera and sangious fluid that formed after clot-lysis.RESULTS:Prazosin, terazosin and alfuzosin,in order, significantly reduced the clot weight up to 3.7%. Peroxynitrite level in sangious fluids was higher in treated groups than that of negative control or sera levels.CONCLUSION:α1-adrenoceptor antagonists induced clot-lysis effect. This effect is associated with generation peroxynitrite

} }