@Article{, title={Clinical Analysis and prognostic Significance of the Methyguanine Methyltransferase in Gastric Colorectal and Breast Cancer}, author={Ali A. Al-katib and Ali Hassan Al-Timimi}, journal={Medical Journal of Babylon مجلة بابل الطبية}, volume={2}, number={4}, pages={444-453}, year={2005}, abstract={Methyl guariine nethyllmnsferase (MGMT) is an enzyme that repairs methyl guanine apromutagenic base damaged by endogenous and environmental alkyl ling agents The expression ofMCMT was immunohistochemically evaluated in 62,53, and 46 paEflin-embedded sa$ples frompatienB with respected grcup 4 gastfic colorcctal and breast cancen respectively theResults showed that the exprcssion of MGMT was positive prediciive factor for overall suNival ingastfic canceE (p <.001) and fof relapse-ftee survival in brcast cancers(p< 00l)MGMTposkive gastfictumo|s (n:42) wcrc correlaled with the absonce of serial invasion (p-045)lvmph Dode meriask(p=006) intestinal type (p=018) and low pathological tumor node metastasis stage (p<001) all breasttumon that rcconed locally al1ef operation were MCMT regalive (p=004) the disease crileria's ofcolofectal canceN with rcspect 1o MGMT expression did not sigDificantly differ 'lt is conchded thatLhe expfession of MGMT is a predicrive pfognostic markef iD patients with gastric and hreastcarreen .these findings may help 10 establisfi therapeutic stmtegies for palicnts lvilh lhesetypes of solid cancer

} }