@Article{, title={The Role of P53 nuclear Protein in Prediction of Progression and Recurrence of Superficial Tumor of the Bladder in Response to Intravesical Chemotherapy}, author={Montadhar Hameed Nima and Rasha Abbas Azeez}, journal={Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية}, volume={10}, number={4}, pages={531-535}, year={2011}, abstract={ABSTRACT:BACKGROUND :p53 gene is the most common mutation in human cancers.In bladder cancer, p53 mutations have beenassociated with high tumor grades and advanced stages.Moreover,p53 nuclear over expressionappears to be an independent predictor of disease progression and decreased survival aftercystectomy.OBJECTIVE:To identify the role of p53 nuclear protein in prediction the progression and recurrence of superficialtumor of the bladder in response to intravesical chemotherapyPATIENTS AND METHOD :The expression of p53 protien was studied by immunohistochemical analysis from 71 patients withsuperficial tumor bladder and all of them were treated by intravesical chemotherapy followedperiodically every three months by cystoscopyRESULT :P53 over expression was observed in 38out of 71(54%) patients with superficial tumor of the bladder.A statisticaly significant relation was noticed between P53 over expression and tumor grades ,however statistical significant relation between p53 negative expression and response to intravesicalmitomycin C chemotherapy was noticed , moreover , patients who received intravesical mitomycinC chemotherapy , 71% showed response with in 3 month , while 29% showed recurrence .Moreover, it seems that P53 status did predict response to intravesical mitomycin C chemotherapy.CONCLUSION :The response of intravesical chemotherapy in patients with superficial transitional cell carcinoma washigher in p53 negative expression.

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