TY - JOUR ID - TI - • An Interaction Study between Acetylsalicylic Acid (Aspirin) and Captopril at Different Doses in Rats AU - Dr. Najah R. Hadi; AU - Duraid A. Abbas AU - Saadia S. Mehdy PY - 2009 VL - 2 no.6, 7 IS - 4 SP - 387 EP - 396 JO - Karbala Journal of Medicine مجلة كربلاء الطبية SN - 19905483 29580889 AB - the present studies were used forty nine rats to determine chronic toxicity effect whichwere divided into 4 groups, the control group (7 rats) received distilled water, the otherthree treatment groups each group (14) rats were divided into two subgroups T1&T2according to the following oral daily dosing regiment ( aspirin subgroup 2 and 4 mg/kg ,captopril, 6 and 12 mg/kg and aspirin + captopril (2 + 6 mg/kg and (4+12 mg/kg) respectively.The following biochemical and hematological results were recorded during the experiment:Prothrombine Time : Captopril, aspirin and captopril + aspirin treated rats showed significantincrease (P < 0.05) in serum PT levels in both T1&T2 subgroups at the period of 1.5 & 3 monthstreatment positively proportional with the dose and treatment period.Clotting Time: No significant changes were noticed in clotting time of aspirin groups andcaptopril treated rat groups, while the combined treated subgroups T1&T2 showed a significantincrease after 3 month.Blood Urea Nitrogen :Captopril, aspirin and captopril + aspirin treated rats showed significantincrease (P < 0.05) in serum BUN levels in both T1&T2 subgroups at the period of 1.5 & 3months treatment positively proportional with the dose and treatment period.Total Body weight : Significant increase in body weight were observed in captopril, aspirin andcaptopril + aspirin treated rats in both T1&T2 subgroups through out the experimental periodsproportional to the do………..se and treatment periods.

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