TY - JOUR ID - TI - Evaluation of Some Spontaneous Abortion-Causative Factors for Women in Baghdad Province A Serological and Histological Study AU - Samar A.AL-Gharrawi AU - Salim R.AL-Ubaidy AU - Bedir M.AL-Azawi PY - 2012 VL - 11 IS - 3 SP - 297 EP - 302 JO - Iraqi Postgraduate Medical Journal المجلة العراقية للاختصاصات الطبية SN - 83601608 98932708 AB - ABSTRACT:BACKGROUND:The spontaneous abortion is considered as one of the important clinical problems that may affects pregnant women during the 1st 20-22 weeks of pregnancy causing dangers to the mother and her fetus. The present study was designed to focus on some spontaneous abortion causes and intrauterine fetal death.OBJECTIVE:Study certain risk factors that may play a role in abortion such as serum level of , progesterone hormone , estradiol hormone , interlukine-6 and perform a histological study on placenta to identify any specific histop-METHODS:Seventy (70) Women were selected to represent the samples of spontaneous aborted women. The women were classified into two groups , the first represented aborted women during the first trimester of pregnancy (52) and the second were females in the second trimester of pregnancy (18) , in comparison with result of (20) normally delivered pregnancies. The samples (sera and placenta) were collected during the period from November 2008 to April 2009 in Baghdad.RESULTS:Significant decrease (p<0.01) in the level of progesterone and estradiol hormone was found in all aborted women at different stages of pregnancy compared with control. There was no significant difference (p>0.05) in level of IL-6 between aborted women and control. There was a correlation (positive) between progesterone with IL-6 in first and second trimester (p<0.05, p<0.01), respectively. And progesterone with estradiol (p<0.05) in second trimester. The histological study shows hydropic degeneration fibroids with hyalinization of fibrinosis changes.CONCLUSION:These results suggest an important role of progesterone, estradiol and IL-6 in spontaneous abortion women during first and second trimester. And apparition of the histological changes corresponding to the aborted women.

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