TY - JOUR ID - TI - In vivo immunohistochemical investegation of bone deposition at collagen coated Ti implant surface AU - Ban A. Al-Ghani بان الغاني AU - Athraa Y.Al-Hijazi عذراء يحيى الحجازي AU - Thair L.AL-Zubaydi Thair L.AL-Zubaydi PY - 2011 VL - 23 IS - special issue SP - 47 EP - 52 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background: Dental implants provide a unique treatment modality for the replacement of lost dentition. Functionalsurface modifications by organic material such as collagen coating seem to enhance early peri-implant boneformation, enhancing the initial cell attachment. The aim of the study was to study the expression of osteocalcin andgrowth hormone receptor as bone formation markers in collagen coated and uncoated implant in intervalperiods(2,and 6 weeks).Materials and Methods: Commercially pure Titanium(cpTi) implants, coated with collagen protein, were placed inthe tibias of 32 New Zealand white rabbits, immunohistochemical tests for detection of expression of osteocalcin andgrowth hormone receptor were performed on all the implants of both control and experimental groups for (2, and 6weeks) healing intervals. Mechanical test (torque removal test) was performed as an indicator for the presence ofosseointegration and as a test for the mechanical property of bone-implant interface, because the torsion appearsto be primarily probing the interface mechanics.Results: Removal torque mean values in all studied groups (uncoated and coated with collagen at two and sixhealing intervals were increasing with advancing time (higher at 6 than 2 weeks periods). And coated implantshowed high value in comparison to control. Results have shown that positive reaction for OC&GHR was expressedby osteoblast cells (OB)at implants coated with collagen ,indicating that bone formation &maturation wasaccelerated by adding biological materials as a modification modality of implant surface..Conclusion: Immunohistochemical findings revealed high positive expression range from strong to moderate ofosteocalcin and GHR in coated implant in comparison to uncoated specialy in early periods.

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