TY - JOUR ID - TI - Efficacy of topical flax paint for the treatment of recurrent aphthous stomatitis AU - Tagreed Altaei تغريد الطائي AU - Shaheen A. Ahmed شاهين احمد AU - Ahmed A. Haider احمد حيدر PY - 2011 VL - 23 IS - special issue SP - 100 EP - 107 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background: Recurrent aphthous stomatitis is commonly observed and is mediated by the immune system. Lesionsappear as painful, tiny, discrete vesicles. Flax (Linum usitatissimum) has antiseptic, anti-inflammatory properties. Thepresent study was a randomized, double-blinded, placebo controlled conducted to assess the efficacy of Flax paintin this disease.Methods: Dermal irritation study; was performed by primary irritation to the skin and measured by a patch-testtechnique on the intact skin of the albino rabbit. Clinical study; 64 RAS patients, randomized to receive Flax paint orplacebo topically (three times a day, for five days). The efficacy of the treatment was estimated (healing time, ulcersize reduction, pain score, change in condition), β-2 microglobulin (β-2M), α-1Antitrypsin (α-1AT), CRP & ESR, Safety,tolerance, side effects were assessed.Results: Dermal irritation test in vivo showed no sign of irritation in Flax paint. Clinical study; four days after treatment,95% of Flax group were completely healed from aphthous ulcers, compared with placebo group ( p < 0.0001). Flaxpaint group showed significant pain reduction after the 1st or 2nd dose application compared to baseline andplacebo. Serum β-2M, α-1AT, CRP, & ESR values showed significant reduction in Flax paint treated group comparedto baseline and placebo. No sign of adverse effects or tolerance.Conclusion: This is the first time reporting that Flax paint reduced the time to repair mucosal tissue (ulcer healing), andpain persistence, it has anti-inflammatory, and analgesic effect. There was no evidence of any adverse effects

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