@Article{, title={Evaluation of serum anti-Cardiolipin antibody, hs-CRP and IL-6 levels in chronic periodontitis as possible risk factors for cardiovascular diseases}, author={Batool H. Al-Ghurabei بتول الغرابي}, journal={Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد}, volume={24}, number={special issue 2}, pages={161-165}, year={2012}, abstract={Background: It has long been established that there is an association between cardiovascular disease andperiodontitis. Evidence shows periodontally infected patients may be at a higher risk of thrombotic accidents viainduced systemic inflammatory mediators’ production and increase in serum levels of autoantibodies such as anticardiolipinantibody. The aim of the present study was to determine the presence of anti-cardiolipin antibody(ACLA)-IgG and -IgM, and to investigate the systemic levels of inflammatory markers of cardiovascular diseases likehigh sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in patients with chronic periodontitisin (CP) as wellas to examine the relationships between these mediators and clinical periodontal parameters.Subjects and Methods: Blood samples were collected from 45 patients with CP (20 with sever periodontitis and 25with moderate periodontitis) and from 30 healthy age matched individuals served as controls. Clinical periodontalparameters used in this study were plaque index, gingival index, probing pocket depth, clinical attachment leveland bleeding on probing. The levels of serum ACLA-IgG, ACLA-IgM, hs-CRP and IL-6 were determined using enzymelinkedimmunosorbent assays.Results: The current results revealed that serum levels of ACLA-IgG, hs-CRP and IL-6 were significantly higher inpatients group as compared to healthy control group (p<0.05, p<0.001), whereas the serum level ACLA-IgM was notobserved any significant differences between two groups (p>0.05). Concerning the comparison between twopatient groups, sever CP group showed significant elevation in serum levels of ACLA-IgG, hs-CRP and IL-6 (p<0.05,p<0.001), while there is no differences in serum level of ACLA-IgM when compared to moderate CP patients group(p>0.05). Furthermore, in regards to the correlation between serum ACLA-IgG, ACLA-IgM, hs-CRP and IL-6, andclinical periodontal parameters, IL-6 level was showed significant positive correlation with clinical attachment level,whereas hs-CRP was showed significant positive correlation with each of probing pocket depth, clinical attachmentlevel and bleeding on probing. Moreover; linear positive correlation was noticed between ACLA-IgG and clinicalattachment level. Conversely, ACLA-IgM level did not show any correlation with clinical parameters of periodontitis(p>0.05).Conclusion: Elevation in prothrombotic autoantibodies, ACLA-IgG and inflammatory mediators (hs-CRP and IL-6)factors may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk forcardiovascular events

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