@Article{, title={Immunohistochemical expression of Basic fibroblast growth factor-2 and Heparanase in oral squamous cell carcinoma}, author={Karrar N. Shareef كرار شريف and Ahlam H. Majeed احلام مجيد}, journal={Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد}, volume={25}, number={1}, pages={94-98}, year={2013}, abstract={Back ground: The aim of this study was to evaluate the expression of fibroblast growth factor-2 and Heparanase inoral squamous cell carcinoma, and to correlate the two studied marker with each other and withclinicopathologicalfinding including grade, stage.Methods: Sections of 30 formalin-fixed paraffin embedded blocks specimens of oral squamous cell carcinoma wereimmunostained to assess the expression of fibroblast growth factor-2 and Heparanse in oral squamous cellcarcinoma cases.Results: The expression of fibroblast growth factor-2 and Heparanase were positive in all oral squamous cellcarcinoma cases (100%). The positive expression of fibroblast growth factor-2 was significantly correlated with tumorsite (p=0.016),and clinical presentation(p-value =0.003).The positive expression of Heparanse was significantlycorrelated with tumor grade(p-value =0.002) .On other hand there was non-significant correlation between fibroblastgrowth factor-2 ,Heparanase and other clinicopathological parameters .Statistically significant correlation was foundbetween the expressions of fibroblast growth factor-2 and Heparanase(p-value= 0.021).Conclusion: The fibroblast growth factor-2 and Heparanase positive expression was noted in all cases of oralsquamous cell carcinomasignifying their important role in the angiogenesis and lymph node metastasis in oralsquamous cell carcinoma, furthermore they cooperate in promoting vascularization, suggesting that fibroblastgrowth factor-2 and heparanase are promising targets for the development of anticancer therapeutics for headand neck malignancies

} }