@Article{, title={Effect of Carbimazol-induced Hypothyroidism on Male Rat Reproductive System تأثير نقص الدرقية المحث بوساطة الكاربيمازول في أعضاء الجهاز التكاثري في ذكور الجرذ}, author={Saadi M. Mahmood and Mohammed N.Taha and Gaida. A. K. Yahia}, journal={Ibn Al-Haitham Journal For Pure and Applied Sciences مجلة ابن الهيثم للعلوم الصرفة والتطبيقية}, volume={26}, number={1}, pages={46-55}, year={2013}, abstract={The present study is undertaken to evaluate the effects of hypothyroidism induced by carbimazol in male rat reproductive system. Rats were treated with carbimazol (80 and 160 mg/kg body weight) daily for two, four, six, and eight weeks, while control rats were given distilled water orally. The results of these experiments are:1-Treatment with carbimazol produced increase in body weight of treated animals. This increase was not statistically significant even at high concentrations.2-Decrease in testicular weight was observed during all administration points. This decrease was aggravated proportional to duration and dose (p≤0.001).3-Results of most intervals showed significant decrease in epididymal-head weight, while no significant decrease was observed in epididymal-tail weight.4-Carbimazol increased seminal vesicle weight, particularly after six (P≤0.05) and eight weeks for both doses.5-Prostates were responsive to reduce thyroid hormones by increasing its weight in a dose-dependent manner.

} }