TY - JOUR ID - TI - Expression of Anti Apoptotic Gene in Exophytic and Endophytic Type of Oral Carcinoma AU - Header Dakhel Al- muala PY - 2010 VL - 3 no.1 IS - 6 SP - 812 EP - 821 JO - Karbala Journal of Medicine مجلة كربلاء الطبية SN - 19905483 29580889 AB - background: Bcl2 is known to belong to a family of apoptosis regulatory geneproducts that may be death antagonist eg (bcl- 2, bcl-xl , mcl –l) or deathagonist ex (bax , bak , bcl -xs , bad) , The bcl- 2 oncoprotein inhibits apoptosisand is expressed by many tumors including carcinoma such as breast ,cervix and headand neck .Aims to identify bcl-2 oncogene product expression of oral carcinoma and itscorrelation to clinical features (exophytic , endophytic and mixed type) of oralcarcinomaPatients and methods Twenty four patients were gathered , 20 patients hadsquamous cell carcinoma and four patients with adenoid cystic carcinoma . Paraffinblocks were obtained of the study group , specimens of follicular lymphoma paraffinblocks were obtained from pathology department at teaching laboratory of medicalcity . Normal oral mucosa were obtained from healthy patients who had undergoneroutine oral surgery following informed consent of the patients .Immunohistochemical procedure of Bcl2 protein were applied .Results our study showed that 11 cases of the exophytic type of oral carcinomarepresented a positive bcl2 expression , 4 cases of the endophytic (ulcerative type)showed a positive immunoreactivity with bcl2 antibodies and 3 cases of mixed type(exophytic type and endophytic) showed a positive bcl2 expression . Statisticalanalysis showed non significant relationship between clinical features (exophytic ,endophytic , Mixed type) and bcl2 expression in oral carcinoma .Conclusion :- bcl-2 expression in normal oral mucosa and oral carcinoma ,bcl-2immunoreactivity was more correlated to mixed type , exophytic and rarely toendophytic oral carcinoma but all didn't reach a statistical significance .Keywords ,anti apoptotic gene product , bcl2 expression , oral carcinoma.

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