TY - JOUR ID - TI - Treatment options of acute viral bronchiolitis in two Iraqi pediatric hospitals with a recent montelukast treatment option. AU - Afrah, G. Salih, افراح جعفر صالح AU - Kassim, J. Al-shamma قاسم الشماع AU - Mahir, M.Hassan ماهر حسن PY - 2013 VL - 13 IS - 2 SP - 87 EP - 94 JO - Al Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية SN - 18150993 2959183x AB - Abstract:Bronchiolitis is a virally induced acute bronchiolar inflammation. It is the mostcommon lower respiratory tract infection in infants with ages less than 1 year.The most common virus responsible for bronchiolitis is respiratory syncytial virus(RSV). The mainstay of management is oxygen and fluid administration. Pharmacologicalinterventions including corticosteroids and bronchodilators have not been shown to improveoutcome.Is to evaluate the effect of montelukast and to verify the efficacy of bronchodilatorsand anti-inflammatory drugs among infants presenting with acute viral bronchiolitis in twoIraqi pediatric hospitals.This was a randomized, prospective study in two Iraqi pediatric hospitals. Sixtyinfants with age range (2-24months) with a first episode of acute bronchiolitis were randomlydivided into four treatment groups: oxygen plus intravenous fluid, montelukast pediatricchewable tablet, salbutamol given in combination as oral plus nebulized salbutamol, anddexamethasone IV injection. Control infants with non respiratory diseases were also studiedfor comparisons. The measured outcomes included: respiratory rate, heart rate, oxygen bloodsaturation, and times to resolution of illness, duration of oxygen & intravenous fluid therapy,and length of hospital stay.These parameters were measured for each infants from hospital admission untildischarge.All groups were comparable at baseline. There are significant improvements in therespiratory rate, heart rate, blood oxygen saturation and rapid resolution of illnesses in thepatients group that received oxygen plus IV fluid &the patients group that receivedmontelukast tablet compared to other treatment options.Length of hospital stays was shorter in these two treatment options compared to othertreatment options.The results observed effect of montelukast & oxygen plus intravenous fluid on themeasured parameters compared to other treatments options in these two hospitals.

الخلاصة :التھاب القصیبات الحاد عند الاطفال ھو مرضشائع یصیب المجاري التنفسیة الصغیرة في الجھاز التنفسي، وھویحدث خلال السنتین الأولیین من الحیاة، وذروة حدوثھ في الأعمار الصغیرة ذات الستة شھور، ویكثر في فصل الشتاءوأوائل الربیع، واحیانا یحدث في الفصول الأخرى ولكن بشكل أقل ویمكن ان یكون بشكل وباء نتیجة لتفشي ذلك الفیروس6 اشھر والذین لم یتغذوا من اثداء امھاتھم - المسبب لھ. أكثر ما یحدث التھاب القصیبات عند الرضع الذكور بین اعمار 3والذین یعیشون في المناطق المزدحمة، عادة ما یكون مصدرالالتھاب الفیروسي ھو من أحد افراد العائلة المصابین بمرضتنفسي بسیط، حیث ان الأطفال الأكبر سنا والبالغین یتحملون ھذا الالتھاب بشكل أفضل من الرضع الذین یعانون الكثیر من ER -