TY - JOUR ID - TI - The effect of intracrevicular injection of fucose on serum interlukine -1beta and tumor necrosis factor alpha AU - Chenar A. Mohammad AU - Khlood A. Al-Safi خلود الصافي AU - Bakhtiar M. Ahmed PY - 2013 VL - 25 IS - 2 SP - 125 EP - 129 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background: α-L-Fucose is a methyl pentose sugar, had the ability to kill bacteria, controlling infection and normalizeimmune function. The objective of this study is to determine the effect of sulcular injection of fucose on rabbitsperiodontium , throughout measuring the level of some proinflammatory cytokine ; interlukine 1beta ( IL-1beta) andtumor necrosis factor ( TNF-alpha) in sera of rabbits before fucose injection and at 3 days after fucose injection.Materials and Methods: The study was carried on using ( 20 ) male rabbits of the same species weighted (1-1.5 kg ) ,the blood samples were collected from hearts of 20 rabbits before fucose injection and consider as( non injectedgroup) , and after 3 days of fucose injection and consider as (fucose injected group) and analyzed fordetermination of the concentration of IL-1ß and TNF-α.Results: The results showed a highly significant decrease in the mean concentration of TNF-α in sera of fucoseinjected group(19.05± 1.166) pg ⁄ml when compared to its mean concentration in non injected group (27.25±7.371)pg ⁄ml ,also a highly significant decrease in the mean concentration of IL-1ß in sera of fucose injected group(34.19 ±3.1)pg ⁄ml as compared to its mean concentration in sera of non injected group (38.86 ±4.565)pg⁄ml.Conclusion: both proinflammatory cytokines were influenced and inhibited by local fucose injection

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