TY - JOUR ID - TI - The study of tempromandibular joint disorders and anticyclic citrullinated peptide antibodies in serum and saliva of patients with rheumatoid arthritis AU - Raya M. Khidhir ريا خضر AU - Raja H. Al-Jubouri رجاء الجبوري PY - 2013 VL - 25 IS - special issue 1 SP - 67 EP - 71 JO - Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد SN - 18171869 23115270 AB - Background: Rheumatoid arthritis is an autoimmune disease that affects mainly the synovial membranes andarticular structures and is characterized by chronic, systemic inflammation involving multiple joints.Being a synovialjoint, the Temporomandibular Joint is subject to the same disorders affecting other synovial joints, including RA.Besideit was considered as a specific serological marker for diagnosing RA disease ,antibodies to cyclic citrullinatedpeptide have proven to be associated with joints destruction, though; it may play a potential role in the predictionof the disease severity.Materials and Methods: Sixty nine individuals (69) were enrolled in this study, forty nine (49) were patients diagnosedwith Rheumatoid Arthritis, and twenty (20) were healthy control subjects. Blood and saliva samples were taken fromeach subject for immunological analysis of Anti-Cyclic Citrullinated Peptides antibodies by ELISA. Each patient withRheumatoid Arthritis disease was examined by means of Research Diagnostic Criteria for Temromandibular Disordersfor the assessment of tempromandibularjoint involvement.Results: Frequency of positive serum Anti-CCP antibodies was higher in rheumatoid arthritis patients compared tohealthy controls (p=0.000).Tempromandibular joint clinical findings were bilaterally involved except joint sounds,sometimes; it was unilateral. Chronic rheumatoid arthritis patients associated with higher prevalence oftempromandibular joint disorders than newly diagnosed RA, except limited mouth opening which were prevalent innewly diagnosed RA patients, (p=0.012) was significant.Positive serum Anti-CCP rheumatoid arthritis patients wereassociated with higher frequency of tempromandibular joint disorderscompared with RA patients with negativeserum Anti-CCP, a non-significant difference was found.Conclusions:Anti-Cyclic Citrullinated Peptide antibodies are considered as a biomarker of inflammation and diseaseactivity. Tempromandibular joint disorders are frequently involved in rheumatoid arthritis patients. Rheumatoid arthritispatients with positive serum Anti-Cyclic Citrullinated Peptides antibodies associated with higher frequency oftempromandibular joint disorders

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