TY - JOUR ID - TI - Beta-Carotene, Glycemic Control And DyslipidemiaIn Type 2 Diabetes Mellitus AU - Hashim M. Hashim AU - Ghassan A.Al-Shamma AU - Hayder Ali Mohammed PY - 2006 VL - 48 IS - 4 SP - 435 EP - 441 JO - Journal of the Faculty of Medicine Baghdad مجلة كلية الطب SN - 00419419 24108057 AB - Background : Diabetes mellitus is a stressful condition in which the increased production of free radicals impairs the generation of naturally occurring antioxidants like vitamins and carotenoids .
Aim :The present study deals with the changes in serum ß-carotene in type 2 diabetes mellitus, as modulated by glycemic control and oxidative stress .
Subjects & methods : Multiple biochemical parameters were obtained from plasma of 57 patients with type 2 diabetes mellitus ( 25 males and 32 females ) , on oral hypoglycemic with a disease duration of 1- 15 years and 37 healthy normal subject s of matching age and sex to serve as controls .
The biochemical parameters measured in the present study included the glycated Hb (HbA1c ), serum lipids ( total cholesterol TC, triglycerides TG , high and low density lipoprotein cholesterols , HDL-C & LDL-C ) , lipid peroxides and serum ß-carotene.
results revealed a marked reduction of ß- carotene in the diabetics in a pattern proportional to that of the glycemic control ,dyslipidemia and oxidative stress .
Possible causes , mechanisms and suggestions underlining these changes are discussed.

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