Abstarct

Ninhydrin is a chemical compound that is commonly used in analytical chemistry. In this research, ninhydrin was utilized to prepare some heterocyclic derivatives. It was reacted with hydrazine to make compound (1), which was the starting material to synthesize other heterocyclic derivatives in this research. These compounds were characterized by (FT-IR) and (H-NMR) techniques. The biological effect of the prepared compounds were tested against the activity of amylase enzyme in serum. These compounds resulted in deactivating the amylase enzyme in a percentage rate of (11.43, 36.49) %, which proves their effectiveness against the enzyme.

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Abstarct

This research included the preparation of new Schiff base ligand derived from 4-aminoantipyrine and o- amino phenol as a first step, and then reacted the result compound with salicylaldehyde to give (2-(4-(2-hydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ylideneamino)phenol(HDPY)) in the second step . Ni(II) complex was prepared with the new ligand .The ligand and its complex was identified by using Uv-Visible,FT-IR and H-NMR spectroscopies and micro elemental analysis by C.H.N.S analyzer and atomic absorption spectrophotometer also by the magnetic susceptibility and molar conductivity measurements . These studies showed that the coordination site of Ni(II) with the ligand through the nitrogen atoms of the two azomethene groups. From these observations we can suggested the square planner geometrical structure for Ni(II) complex

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