Synthesis of different heterocyclic compounds derived from some amino acids

Abstract

Abstract: Some of heterocyclic compounds have been synthesized using some amino acids as a starting materials provides that the synthesized products bear parts of the amino acids structure. The types of these compounds are pyrazoles, pyridazines, thiazepines, and oxazepines. A preliminary test to evaluate the antimicrobial potency of some of the synthesized compounds were carried out using two types of organisms (+ve) and (-ve). The tests demonstrated an encouraging results for a good number of the tested compounds.1-Introduction The synthesis of heterocyclic compounds has received a considerable attention because of the different types of these compounds have various applications such as in pharmaceutical, agrochemical and industry[1-5]. Some of these compounds displayed wide spectrum of activities such as antibacterial, anti-inflammatory, antidepressant, antihistaminic, anticonvulsant and other activity[6-12]. A various procedures for the synthesis of different heterocyclic derivatives were developed including those for pyrazoles , pyridazines, thiazepines and oxazepinZes[13-25] . The derivatives of these types have various substituents in order to estabilish a conclusion reflects the chemical structure – biological activity relationship. The coal of this work is to synthesis some new heteroyclic derivatives incorporated in their structures a substantial part of different amino acids. The synthesis of these compounds requires the convertion the amino a acids into it is hydrazides, Acid chlorides,thioureas and shiff- bases. 2-Experimental Melting points were recorded using SMP 30 melting point instrument (Stuart, Germany), and they are uncorrected. 1H nmr spectra were recorded in DMSO-d6 on Bruker( 400 MHZ) DMX-500 NMR spectrophotometer, at Al- albayt university , Jordan. The chemical shifts were recorded as values