Levels of Liver Enzymes and Some Changes in Renal Functions in Iraqi Hypothyroid Patients Women

Abstract

The present study aimed to investigate physiological disorders in some liver and kidney functions in hypothyroid Iraqi women .The study was carried on 120 subjects in the Specialist Center of Endocrine and Diabetic diseases at Rusafa region, near AL-Kindey Hospital . That study began on 20/10/2013 to 25/1/2014 The subjects were divided into 4 groups (control, euthyroid ,subclinical and overt hypothyroid).Each group included 30 females ,their ages ranged (39.45 ±1.79) years. The results showed a significant(P˂ 0.05) increase in the level of TSH in subclinical (18.23 ± 2.34mu/l) and overt hypothyroid patients (41.37 ± 3.75 mu/l) in comparison with control (2.09 ± 0.23mu/l) and euthyroid groups (2.89 ± 0.20mu/l). The levels of T4 and T3 were within the normal limits in control (79.73 ± 2.11 nmol/L);(1.70 ± 0.07nmol/L),euthyroid (87.10 ± 2.16 nmol/L) ; (1.58 ± 0.05nmol/L) and subclinical (77.76 ± 2.31nmol/L) ; (1.52 ± 0.08 nmol/L)respectively. While overt hypothyroid group showed a significant (P˂0.05) decrease in T4 level (46.36 ± 2.32 nmol/L) with normal T3(1.30 ± 0.11 nmol/L). The changes in liver function tests in overt hypothyroid group showed a significant (P˂0.05) increase in the levels of SGOT (23.05 ± 2.67U/L),SGPT(21.89 ± 2.35 U/L) and ALP(99.98 ± 7.47 U/L) in comparison with SGOT in control (8.80 ± 0.88 U/L) , euthyroid (11.36 ± 0.85 U/L) and subclinical (11.88 ± 1.42 U/L) and SGPT in control (13.46 ± 0.75 U/L) euthyroid (10.93 ± 1.03 U/L), and subclinical (14.08 ± 1.87 U/L) and in the level of ALP in control(50.27 ± 2.65 U/L),euthyroid (65.27 ± 2.87 U/L) and subclinical(71.58 ± 4.90 U/L) respectively. Total serum protein(7.49 ± 0.16 g/dl) and bilirubin (1.23 ± 0.11 mg/dl) were increased significantly (P˂ 0.05) in overt hypothyroid patients in comparable with control (6.82 ± 0.04 gm/dl) ; (0.613 ± 0.04