SYNTHESIS AND CHARACTERIZATION OF SOME NEW PYRROLIDINE-2,5-DIONE DERIVATIVES USING ANTHRANILIC ACID

Abstract

Depending on anthranilic acid as a starting material tow amides 1 and 2 were synthesized through the nucleophilic substitution reaction with both 2-chloro- benzoylchloride and acetic anhydride respectively, which were then reacted with hydrazine hydrate or phenylenediamine respectively to produce the corresponding quinazolinones (3 and 4). These compounds in turn were reacted with phthalic anhydride and succinic anhydrides respectively to produce the corresponding pyrrolidine-2,5-dione derivatives (5, 6, 7 and 8). All the synthesized compounds were characterized through their physical properties and identified using the spectroscopic techniques which is: FT- IR and 1H NMR techniques.