The Liver Aminotransferase Levels in Diabetes Patients

Abstract

This study aim toinvestigate the levels ofliver aminotransferase in patients with diabetes and the effect of glycemic control on the levels of these enzymes.The study was conducted on 115 persons, 19 poorly controlled diabetic patients (glucose>300 mg/dl), 25 moderately controlled diabetic patients (glucose 200-300 mg/dl), 21 well controlled diabetic patients (glucose < 200 mg/dl), and 50healthy non diabetic subjects as normal control. Serum glucose, ALT and ASTwere assessed in all groups.There was no statistically difference in ALT and AST levels between control and total diabetes patient groups. Poorly controlled diabetic patients demonstrated highly significantly increase of ALT and AST when compared with the other two patient groups (well and moderate controlled diabetic). But there is no significant statistic for these enzymes between well and moderate controlled diabetic groups. In conclusion,increased levels of ALT and ASTmay contributory factor to induced liver disease observed in poorly glycemic control patients.