The preemptive role of C and E vitamin against deleterious role of bisphenol A in Albino rats on tissue changes in liver and kidney

Abstract

This study was carried out at the college of Veterinary Medicine, Kerbala University to determine the effect of pre- and postnatal exposure to Bisphenol A (BPA) on histopathology of Liver and Kidney Thirty pregnant female rats (F0) were divided to six groups the first group gave corn oil as control group and 2 positive control groups the first group treated with vitamin C concentration 500 mg and another group treated with vitamin E concentration 200 mg the fourth group treated one dose of BPA suspended in corn oil 200 mg/kg/BW ,the fifth one treated with BPA and vit. E concentration 500 mg . and the sixth group treated with BPA and vit. C 500 mg concentration from gestational day (GD) 6 through postnatal day (PND) 21. The weanlings (F1) from all treated groups(6 of each group) then were subjected to necropsy 3 months of age. The results of Histopathologic effects of Bisphenol A on liver and kidney of male rats showed that the treatment with BPA or BPA with antioxidant (C+E) resulted in deleterious effects in liver and kidney.From the present study it has been revealed that the antioxidant vitamins C and E don’t have preemptive role against deleterious role of bisphenol A