Renal Fluoride excretion in children following topical application of acidulated phosphate fluoride and sodium fluoride

Abstract

AbstractThe aim of this study was to demonstrate that if there is an increase in urinaryfluoride and creatinine excretion and F/ Cr ratio after application of acidulatedphosphate fluoride APF and sodium fluoride NaF fluoridated gel.The sample chosen consisted of 80 children randomly selected, aged 9-11 yearsold, lived in Baghdad city with non-fluoridated water areas. The children weredivided into two groups, the study group which consists of 60 children who receivedthe topical fluoridated gel, the acidulated phosphate fluoride (APF) and the sodiumfluoride (NaF).Urinary samples were taken from them before the topical applicationof dental fluoride gel APF and NaF and 2 hours afterwards. In an age matched controlgroup of 20 children from the same community, who received no treatment, sampleswere taken at the same way. The urinary excretion of fluoride was analyzed bydetermining fluoride ion (F-) level and fluoride/ creatinine (F/ Cr) ratio in the urine.Results showed that the mean F ion before and 2 hours after acidulated phosphatefluoride application APF was (1.74 and 2.36) respectively, this difference wasstatistically highly significant (p<0.001). While the F/ Cr ratio before and 2 hoursafter APF application was (1.01 and 1.07) respectively, with no significant difference(P<0.05). The mean of F ion before and 2 hours after sodium fluoride application NaFwas (1.74 and 3.18) respectively, the difference was highly significant (p<0.001).While the F/ Cr ratio before and 2 hours after NaF application was (1.16 and 1.33)respectively with no significant difference (p<0.05). In the control group nosignificant changes occur (p<0.05).