9-PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus)

Abstract

The oral use of pregabalin was evaluated in this study to reveal its effects onsome hematological and biochemical parameters of laboratory mice. The animals ofthis study were divided into three groups (twelve mice each). The control group wasfed on a standard ration. The first treated group (Pregabalin 1) were dosed orally withone ml of distilled water containing Pregabalin (20 mg/ml/mice/ day). The secondtreated group (Pregabalin 2) were dosed orally with one ml of distilled watercontaining pregabalin (40mg/ml/mice/ day). The experiment continued for twosuccessive months. The results showed that the use of pregabalin caused a significantdeclination in R.B.C., HGB, HCT, W.B.C., M.C.V., MCH, and MCHC of bothtreated groups compared them with control group and the declination was moresignificant in (pregabalin 2) group compared with (pregabalin 1) group. The RDWCV, RDW-SD, and PLT increased significantly in both treated groups as comparedwith those of the control group. However, PCT, PDW and MPV were not affected bythe use of pregabalin except the MPV of (Pregabalin 2) group was significantly lessthan that of (Pregabalin 1) but without a significant difference compared with that ofcontrol. The Fe++, and GLU decreased significantly in both treated groups comparedwith the control and they declined more significantly in (Pregabalin 2) compared with(Pregabalin 1). Both the TP and Ca++ did not affected by the use of pregabalincompared with the control group (P≤0.05)